NanoCare

A German Initiative on the Health Aspects of Synthetic Nanoparticles:

Establishing an Information- and Knowledge-Base for Innovative Material Research

The NanoCare project (running from 2006 until 2009) aimed at broadening the knowledge about synthetic nanomaterials with regard to the potential impacts of nanomaterials on human health. New innovative applications and measurement methods were developed for a sustainable and caretaking use of chemical nanotechnology.

Data created within NanoCare were interpreted together with additional information from literature and then published by the “knowledgebase”. This publication of nanotechnology safety aspects satisfied increasing information needs of the public. Furthermore, the results were presented to and discussed with the interested public, politicians and NGOs at dialogue events. Partners from industry, universities and research institutes were contributing their expertise to this partnership.

Project Lead

Prof. Dr. Harald Krug, Forschungszentrum Karlsruhe GmbH (seit März 2009 Empa, St. Gallen, Schweiz) (03/2006 - 02/2009)

PD Dr. Thomas Kuhlbusch, Institut für Energie- und Umwelttechnik e.V. (IUTA) (03/2009 - 07/2009)

Web Coordination

Dr. Katja Nau, Forschungszentrum Karlsruhe GmbH (seit 2009 Karlsruher Institut für Technologie - KIT)

Project Partner

Forschungszentrum Karlsruhe GmbH

Institut für Energie- und Umwelttechnik e.V. (IUTA)

BASF

NanoMAT

Bayer MaterialScience

Dechema

Evonik

IBE R&D GmbH

Institut für Gefahrstoff-Forschung (IGF)

ItN Nanovation

Solvay

SusTech Darmstadt

University of Bielefeld

Saarland University

VDI Technologiezentrum

University of Münster

Publications

2011

Interference of engineered nanoparticles with in vitro toxicity assays. Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Arch Toxicol, 86(7): 1123-1136..
Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays. Kroll A, Dierker C, Rommel C, Hahn D, Wohlleben W, Schulze-Isfort C, Göbbert C, Voetz M, Hardinghaus F, and Schnekenburger J Part Fibre Toxicol, 8(1): 9.

2009

Interaction of metal oxide nanoparticles with lung surfactant protein A. Schulze C, Schaefer UF, Ruge CA, Wohlleben W, Lehr CM. Eur J Pharm Biopharm, 77(3): 376-383.
Testing Metal-Oxide Nanomaterials for Human Safety Landsiedel R, Ma-Hock L, Kroll A, Hahn D, Schnekenburger J, Wiench K, Wohlleben W. 2010 Adv Mater, 22(24): 2601-2627.
Investigation of airborne nanopowder agglomerate stability in an orifice under various differential pressure conditions Stahlmecke B, Wagener S, Asbach C, Kaminski H, Fissan H, Kuhlbusch, TA J. 2009 J Nanopart Res, 11(7): 1625-1635.
Comparison of four mobility particle sizers with different time resolution for stationary exposure measurements. Asbach C, Kaminski H, Fissan H , Monz C, Dahmann D, Mülhopt S, H-R Paur, Kiesling HJ, Herrmann F, Voetz M, Kuhlbusch TAJ. 2009 J Nanopart Res 11(7): 1593-1609.
The NanoCare project: a German initiative on health aspects of synthetic nanoparticles Nau K, Krug HF. 2009 Journal of Physics: Conference Series, 170(1): 012038.
Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size. Pauluhn J. 2009 Toxicol Sci, 109(1): 152-167.
Genotoxicity Investigations on Nanomaterials: Methods, Preparation and Characterization of Test Material, Potential Artifacts and Limitations - Many Questions, Some Answers. Landsiedel R, Schulz M, Kapp MD, Oesch F. 2009 Mutat Res, 681(2-3): 241-258.
Current in vitro methods in nanoparticle risk assessment: Limitations and challenges Kroll A, Pillukat MH, Hahn D, Schnekenburger J. 2009 Eur J Pharm Biopharm, 72(2): 370-377.
Development of a short-term inhalation test in rats using nano-titanium dioxide as a model substance. Ma-Hock L, Burkhardt S, Strauss V, Gamer A, Wiench K, van Ravenzwaay B, Landsiedel R. 2009 Inhal Toxicol, 21(2): 102-118.

2008

In Vitro exposure systems and bioassays for the assessment of toxicity of nanoparticles to the human lung Paur H-R, Mülhopt S, Weiss C, Diabaté S. 2008 Journal für Verbraucherschutz und Lebensmittelsicherheit, 3 (3).
Nanotechnologie – Zwerge erobern den Alltag Krug HF. 2008 Chemie Ingenieur Technik, 80(11): 1653-1660.
Geeignete Methoden zur Prüfung der Sicherheit von Nanomaterialien Landsiedel R, Wiench K, Wohlleben W. 2008 Chemie Ingenieur Technik, 80(11): 1641-1651.
Not ready to use - overcoming pitfalls when dispersing nanoparticles in physiological media. Schulze C, Kroll A, Lehr C-M, Schäfer UF, Becker K, Schnekenburger J, Schulze Isfort C, Landsiedel R, Wohlleben W. 2008 Nanotoxicology, 2(2): 51-61.

2007

Generation and Characterization of Test Atmospheres with Nanomaterials. Ma-Hock L, Gamer A, Landsiedel R, Leibold E, Frechen T, Sens B, Huber G, van Ravenzwaay B. 2007 Inhal Toxicol, 19(10): 833-848..

Wissenschaftlicher Abschlussbericht, Juli 2009 (englisch): Health related Aspects of Nanomaterials, Final Scientific Report (PDF, 19 MB )
NanoCare-Broschüre , 2009, Gesundheitsrelevante Aspekte synthetischer Nanomaterialien (PDF, 2,6 MB )

PDF-Dokumente zum Download :

Begriffsglossar zu den Standardarbeitsanweisungen für Arbeitsplatzmessungen im Rahmen von NanoCare

Bürgerdialog: "Nanotechnologie sicher gemacht", 29. November 2008 Dresden, Japanisches Palais, Flyer zur Veranstaltung (Dresden) (234 KB)
Bürgerdialog: "Gesundheitliche Wirkungen von Nanopartikeln", 27. September 2008 München, Deutsches Museum, Flyer zur Veranstaltung (München) (234 KB)
Bürgerdialog: "Sichere Herstellung von Nanomaterialien", 12. April 2008 Hamburg, Hauptgebäude der Universität, Flyer zur Veranstaltung (Hamburg) (855 KB)

16.-17. Juni 2009 in Berlin, Jerusalemkirche: Programm

Vortragsfolien

Schlaglichter (Thomas Kuhlbusch)
Die Eckpunkte von NanoCare (Thomas Kuhlbusch)
Materialcharakterisierung (Christian Göbbert)
In-vitro-Studien (Jürgen Schnekenburger)
In-vivo-Studien (Robert Landsiedel)
Exposition (Christof Asbach)
Zusammenfassung (Harald Krug)

Poster:

Asbach et al.: Intercomparability study of electrical mobility particle sizers
Grimm et al.: Real Time Monitoring Instrument
Kroll et al.: In vitro toxicity screening
Kühnel et al.: Toxikologische Untersuchung von Hartmetall-Nanopartikeln
Meissner et al.: Partikel- und Suspensionscharakterisierung
Mülhopt et al.: Karlsruher Expositionssystem
Pillukat et al.: Induction of cytokine expression
Scholz et al.: Das INOS-Virtuelle Labor
Stahlmecke et al.: Agglomerate Stability
Wesner et al.: Wechselwirkungen zwischen Nanopartikeln und Zellen