In this collaborative project, an innovative device-based method was developed to screen airborne (nano)materials for their toxic<\/span> effects. For this purpose, an exposure<\/span> unit was established to expose human alveolar lung models at the air-liquid interface to the materials. In parallel, an integrated microfluidic two-organ chip was developed that combines the human alveolar lung model with a human liver model and ensures long-term co-culture<\/span> by continuous medium perfusion of the organ models. The functionality was demonstrated using biological parameters for the lung and liver. By combining the device and the two-organ chips, the prototype of an animal-free, compact NanoCube system for the assessment of human exposure to inhaled nanomaterials<\/span> in the working environment was developed. The severe delays in the project schedule caused by the Corona pandemic were almost completely made up by a cost-neutral 9-month project extension. However, the final feasibility study could not be completed within this timeframe. The partners are currently searching for a suitable funding of this final step.<\/p>\n","protected":false},"template":"","cluster":[80],"modul":[],"class_list":["post-9460","project","type-project","status-publish","hentry","cluster-nanocare4-0-reliable-material-innovations-the-new-bmbf-funding-measure"],"acf":[],"yoast_head":"\n