{"id":9480,"date":"2015-06-23T14:08:35","date_gmt":"2015-06-23T14:08:35","guid":{"rendered":"https:\/\/dana.ggiants.de\/forschung\/projekte\/nanobel\/"},"modified":"2025-03-31T17:01:13","modified_gmt":"2025-03-31T15:01:13","slug":"nanobel","status":"publish","type":"project","link":"https:\/\/materialneutral.info\/en\/project\/nanobel\/","title":{"rendered":"NanoBEL"},"content":{"rendered":"<h3 style=\"text-align: left;\">NanoBEL &#x2013; <span style=\"text-decoration: underline;\">B<\/span>iological <span style=\"text-decoration: underline;\">El<\/span>imination of Complex Diagnostic <span style=\"text-decoration: underline;\">Nano<\/span>particles<\/h3>\n<figure id=\"attachment_4788\" aria-describedby=\"caption-attachment-4788\" style=\"width: 368px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-4788 \" src=\"https:\/\/nanopartikel.info\/wp-content\/uploads\/2020\/10\/NanoBEL-Projekt-Image.png\" alt=\"NanoBEL medical applications (c) NanoBEL Consortium\" width=\"368\" height=\"497\"\/><figcaption id=\"caption-attachment-4788\" class=\"wp-caption-text\">NanoBEL medical applications (c) NanoBEL Consortium<\/figcaption><\/figure>\n<p>&#xA0;<\/p>\n<p style=\"text-align: left;\">Nanotechnology is one of the key technologies of the 21st century that developed from a basic research to a worldwide important discipline in the last years with an enormous importance in life sciences and medicine. Magnetic nanoparticles play an important role in diagnostic imaging for prevention, therapeutic monitoring and therapy.<\/p>\n<p style=\"text-align: left;\">Whereas the toxicological effects of <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_93be66cbd5f71123f8da06a7a42c7627\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>acute<\/span> <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_29fd131a0d512eb1f0aa4ee91141bd26\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">nanoparticle<\/span> expositions were widely described in the last years, long-term risks depending on the structure of the <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_b9e9395286233f41aea957abe9492004\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">nanomaterials<\/span> and the disease state of the patients have not been systematically investigated.<\/p>\n<p style=\"text-align: left;\"><strong>NanoBEL<\/strong> is focused on the risk assessment of the long-term effects of magnetic nanoparticle exposition particularly after repeated administrations, as well as the role of degradation and elimination in the life-cycle of the nanoparticles in diseases like cancer and <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_15f3295e0487b3d3caadfbdae8ed0777\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">inflammation<\/span>. Innovative magnetic nanoparticle formulations with a high relevance for future diagnostic applications are taken into consideration. Beside the development and optimization of magnetic nanoparticles,<\/p>\n<p style=\"text-align: left;\">NanoBEL contributes to the development and validation of new alternatives to animal-based methods (cell cultures, hen&#x2019;s egg models) to be applied in an integrated safety assessment of the long-term administration of nanoparticles. In close collaboration with <a title=\"DaNa2.0 Project\" href=\"https:\/\/nanopartikel.info\/en\/research\/projects\/dana-2-0\/\" rel=\"noopener noreferrer\">DaNa<sup>2.0<\/sup><\/a>, the systematic collection of the data in a data base accomplish the categorization of nanomaterials, the identification of relevant endpoints, and the risk management.<\/p>\n<p>&#xA0;<\/p>\n<p>&#xA0;<\/p>\n<p>&#xA0;<\/p>\n<p>&#xA0;<\/p>\n<p>&#xA0;<\/p>\n","protected":false},"template":"","cluster":[82],"modul":[],"class_list":["post-9480","project","type-project","status-publish","hentry","cluster-2014-2018-nanocare-2-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NanoBEL - MANTRA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/materialneutral.info\/en\/project\/nanobel\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NanoBEL - MANTRA\" \/>\n<meta property=\"og:description\" content=\"NanoBEL \u2013 Biological Elimination of Complex Diagnostic Nanoparticles &nbsp; 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