{"id":9490,"date":"2014-10-17T09:09:18","date_gmt":"2014-10-17T09:09:18","guid":{"rendered":"https:\/\/dana.ggiants.de\/forschung\/projekte\/nanoumwelt\/"},"modified":"2025-03-31T17:01:14","modified_gmt":"2025-03-31T15:01:14","slug":"nanoumwelt","status":"publish","type":"project","link":"https:\/\/materialneutral.info\/en\/project\/nanoumwelt\/","title":{"rendered":"NanoUmwelt"},"content":{"rendered":"<h3 style=\"text-align: left;\">NanoUmwelt &#x2013; Risk analysis of engineered nanomaterials in the environment: identification, quantification and analysis of the human- and ecotoxicological effects<\/h3>\n<p style=\"text-align: left;\">Aim of the project <strong>NanoUmwelt<\/strong> was to quantify the entry of engineered <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_b9e9395286233f41aea957abe9492004\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">nanomaterials<\/span> into various environmental compartments, to characterise their form of appearance and to develop a deeper understanding of their eco- and human-toxicological impact using novel analytical methodologies and scientifically sound analyses. The data generated within NanoUmwelt shall serve as a reliable basis for a realistic risk assessment of nanomaterials after their entry into the environment and for the development of appropriate recommendations for novel regulations with regard to the protection of human life and the environment.<\/p>\n<figure id=\"attachment_9180\" aria-describedby=\"caption-attachment-9180\" style=\"width: 542px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-9180\" title=\"Nanoumwelt-projectplan\" src=\"https:\/\/nanopartikel.info\/wp-content\/uploads\/2020\/11\/Nanoumwelt-project-plan.png\" alt=\"Nanoumwelt project plan\" width=\"542\" height=\"435\" srcset=\"https:\/\/materialneutral.info\/wp-content\/uploads\/2020\/11\/Nanoumwelt-project-plan.png 579w, https:\/\/materialneutral.info\/wp-content\/uploads\/2020\/11\/Nanoumwelt-project-plan-300x241.png 300w\" sizes=\"(max-width: 542px) 100vw, 542px\"\/><figcaption id=\"caption-attachment-9180\" class=\"wp-caption-text\">NanoUmwelt Projectplan<\/figcaption><\/figure>\n<p style=\"text-align: left;\">Against this background, <strong>NanoUmwelt<\/strong> had dealt with three different tasks:<\/p>\n<ol style=\"list-style-type: lower-alpha; text-align: left;\">\n<li><em>the detection and quantification of smallest amounts of nanomaterials (&lt;ng\/L or &lt;ng\/kg) in environmental and human samples<\/em><\/li>\n<li><em>the <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_fdb8b55a8eca6aa21c3383e316dcdca4\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">in vitro<\/span> investigation of the human- and ecotoxicity in the low-dose range<\/em><\/li>\n<li><em>the standardised and reproducible synthesis of nanomaterials<\/em><\/li>\n<\/ol>\n<h4 style=\"text-align: left;\"><\/h4>\n<h4 style=\"text-align: left;\"><strong>The most important developments within NanoUmwelt are:<\/strong><\/h4>\n<ul style=\"text-align: left;\">\n<li style=\"text-align: justify;\">A standardised sample preparation protocol for the analysis of engineered nanomaterials in complex human and environmental samples such as human blood, fish tissues and mussels<\/li>\n<li style=\"text-align: justify;\">Powerful analytical methodologies based on Transmission <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_a74c6713fadb34aeb69a3b129cc810cf\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Electron Microscopy<\/span> (<span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_5d5f11b803aeafb5b36ca8075200b058\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>TEM<\/span>), Immunoassays (ABICAP) and Asymmetrical Flow Field-Flow Fractionation (AF4) for the quantification and characterization of engineered nanomaterials in complex human- and environmental samples down to trace levels (&lt;&micro;g\/L)<\/li>\n<li style=\"text-align: justify;\">Novel <em>in vitro<\/em>&#x2013; and <em><span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_5d77a2776803c180bda98eb644d6de44\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>ex vivo<\/span><\/em>-models for the investigation of human-toxicological effects of nanomaterials based on endpoints like cardiotoxicity, immune reaction, differentiation potential and transport across biological barriers<\/li>\n<li style=\"text-align: justify;\">Novel model systems for the investigation of ecotoxicological effects of nanomaterials<\/li>\n<\/ul>\n<h4 style=\"text-align: left;\"><\/h4>\n<h4 style=\"text-align: left;\"><strong>The most important findings of NanoUmwelt are:<\/strong><\/h4>\n<ul>\n<li style=\"text-align: left;\">The concentrations of engineered nanomaterials in all investigated real samples were below the limits of quantification of the analytical methodologies developed within NanoUmwelt<\/li>\n<li style=\"text-align: left;\">A long-term <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_5bd815081aef5477a0b0a38216d0fcaa\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">exposure<\/span> of <a title=\"Silver, Overview, DaNa Knowledge Base\" href=\"https:\/\/nanopartikel.info\/en\/knowledge\/materials\/silver\/\" rel=\"noopener noreferrer\">silver<\/a> (AgPure) and <a title=\"Wikipedia (EN): Polystyrene\" href=\"http:\/\/en.wikipedia.org\/wiki\/Polystyrene\" target=\"_blank\" rel=\"noopener noreferrer\">polystyrene<\/a> nanoparticles in soil has significant impact on soil microbial and <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_3d354e7574b9465534728a36bf3fa6e5\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>enzyme<\/span> activities as well as the functional diversity of the soil microbial community (<a title=\"https:\/\/doi.org\/10.1016\/j.jes.2018.04.013\" href=\"https:\/\/doi.org\/10.1016\/j.jes.2018.04.013\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1016\/j.jes.2018.04.013<\/a>; <a title=\"https:\/\/doi.org\/10.1186\/s12302-018-0140-6\" href=\"https:\/\/doi.org\/10.1186\/s12302-018-0140-6\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1186\/s12302-018-0140-6<\/a>)<\/li>\n<li style=\"text-align: left;\">Uptake of polystyrene nanoparticles into human cells could be observed, however, no influence on the cell viability was evident in the low-dose range<\/li>\n<li style=\"text-align: left;\">No conclusive statement on the permeability of biological barriers for engineered nanomaterials can be drawn, yet<\/li>\n<li style=\"text-align: left;\">Model systems of the intestinal and placental barrier represent very suitable tools for the investigation of the transport of nanomaterials in the human organism. The selection of the respective model (2D-<em>in vitro<\/em>, 3D-<em>in vitro<\/em> or <em>ex vivo)<\/em> is crucial with regard to the results of the performed studies. It could be demonstrated that, depending on the applied model system, nanoparticles can partially induce different effects. Hence, the proper choice of the applied model system is a very critical parameter in human <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_dc606f1af1af41ffeea7665ed0a7b846\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">toxicology<\/span><\/li>\n<\/ul>\n","protected":false},"template":"","cluster":[82],"modul":[],"class_list":["post-9490","project","type-project","status-publish","hentry","cluster-2014-2018-nanocare-2-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NanoUmwelt - MANTRA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/materialneutral.info\/en\/project\/nanoumwelt\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NanoUmwelt - MANTRA\" \/>\n<meta property=\"og:description\" content=\"NanoUmwelt &#8211; 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