{"id":9519,"date":"2024-07-15T13:49:29","date_gmt":"2024-07-15T11:49:29","guid":{"rendered":"https:\/\/dana.ggiants.de\/forschung\/projekte\/nanogem\/"},"modified":"2025-04-01T15:32:37","modified_gmt":"2025-04-01T13:32:37","slug":"nanogem","status":"publish","type":"project","link":"https:\/\/materialneutral.info\/en\/project\/nanogem\/","title":{"rendered":"nanoGEM"},"content":{"rendered":"<h3>nanoGEM &#x2013; Nanostructured Materials &#x2013; health, exposure and material properties<\/h3>\n<p>&#xA0;<\/p>\n<p>The <strong>NanoGEM research project<\/strong>, funded by the BMBF and industry, was an integrative interdisciplinary project that carried out various research activities on nanosafety, <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_5bd815081aef5477a0b0a38216d0fcaa\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">exposure<\/span>, risk, and <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_dc606f1af1af41ffeea7665ed0a7b846\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">toxicology<\/span> in a combined effort of academia, authorities and industry. The results and findings obtained within NanoGEM were published in international journals (see NanoGEM publications) and included in the international harmonisation process and the public dialogue. In addition, practical safety proposals and standard operating procedures (SOP) were developed and published.<\/p>\n<p>The specific research activities were divided into <strong>seven work packages<\/strong>. Knowledge of the basic properties of <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_b9e9395286233f41aea957abe9492004\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">nanomaterials<\/span> (<span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_5b2fd8161c6fc3619afcfb9fcf641fb8\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>NM<\/span>) plays an essential role in the investigation and assessment of safety issues relevant to humans and the environment.<\/p>\n<figure id=\"attachment_9364\" aria-describedby=\"caption-attachment-9364\" style=\"width: 601px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-9364 size-full\" title=\"NanoGEM Project Description\" src=\"https:\/\/nanopartikel.info\/wp-content\/uploads\/2020\/11\/NanoGEM-Project-Description.png\" alt=\"NanoGEM Project Description\" width=\"601\" height=\"432\" srcset=\"https:\/\/materialneutral.info\/wp-content\/uploads\/2020\/11\/NanoGEM-Project-Description.png 601w, https:\/\/materialneutral.info\/wp-content\/uploads\/2020\/11\/NanoGEM-Project-Description-300x216.png 300w\" sizes=\"(max-width: 601px) 100vw, 601px\"\/><figcaption id=\"caption-attachment-9364\" class=\"wp-caption-text\">NanoGEM Project Description<\/figcaption><\/figure>\n<p><strong>The work packages &#x201C;production, functionalisation and characterisation of nanomaterials&#x201D;<\/strong> mainly dealt with the development and allocation of new materials with modified basic properties, and modified surfaces in particular. The surfaces of selected nanomaterials such as <a href=\"https:\/\/nanopartikel.info\/en\/knowledge\/materials\/silver\/\" rel=\"noopener noreferrer\">silver<\/a> (Ag), <a title=\"Silicon Dioxide Overview, DaNa Knowledge Base\" href=\"https:\/\/nanopartikel.info\/en\/knowledge\/materials\/silicon-dioxide\/\" rel=\"noopener noreferrer\">silicon dioxide<\/a> (SiO<sub>2<\/sub>), and <a title=\"Zirconium Dioxide Overview, DaNa Knowledge Base\" href=\"https:\/\/nanopartikel.info\/en\/knowledge\/materials\/zirconium-dioxide\/\" rel=\"noopener noreferrer\">zirconium dioxide<\/a> (ZrO<sub>2<\/sub>) were specifically modified and thoroughly characterised in water and relevant biological media together with other reference and comparison materials. Labelling of silicon dioxide and <a title=\"Titanium Dioxide Overview, DaNa Knowledge Base\" href=\"https:\/\/nanopartikel.info\/en\/knowledge\/materials\/titanium-dioxide\/\" rel=\"noopener noreferrer\">titanium dioxide<\/a> (TiO<sub>2<\/sub>) nanoparticles with the fluorescent marker FITC (fluoresceine isothiocyanate) allowed for identification, localisation and mobility tracking of these nanoparticles in different media.<\/p>\n<p>Studies within the <strong>work package &#x201C;exposure &#x2013; measuring techniques and scenarios&#x201D;<\/strong> investigated the basic principles required for exposure assessment, release mechanisms and measuring strategies. The results of the main questions like <em>&#x201C;Is it possible to reproduce and simulate certain release scenarios in the laboratory in a comparable way?&#x201D;<\/em> and &#x201C;<em>Which measuring techniques and strategies can be used for exposure studies?&#x201D;<\/em> were integrated into a testing strategy which meanwhile has been included in the <a title=\"Organisation for Economic Co-operation and Development (OECD)\" href=\"http:\/\/www.oecd.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_0987e2e3b8e96f147ef1a544c69b5318\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>OECD<\/span><\/a> program of the <a title=\"OECD Working Party of Manufactured Nanomaterials (WPMN).\" href=\"http:\/\/www.oecd.org\/science\/nanosafety\/\" target=\"_blank\" rel=\"noopener noreferrer\">Working Party of Manufactured Nanomaterials (WPMN)<\/a>.<\/p>\n<p>In a special work package called <strong>&#x201C;cross-cutting issues: nanomaterial modifications&#x201D;<\/strong>, modifications of the properties of nanomaterials over the entire life cycles were analysed placing emphasis on the lungs as the most health-relevant routes of entry of nanomaterials into the body.<\/p>\n<p>Surface functionalisation had an essential influence on the <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_53da6a5c8d65e0d88966d9fcef5f0e3b\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">adsorption<\/span> behaviour of the lung surfactant lipids&rsquo; towards the nanomaterials such that after attachment of the different components (lipids, proteins, organic compounds), there was no direct contact between the surface of the nanomaterials and the surrounding medium. In the <span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_52a2da23d7bb9b263aa23827973e9ba9\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>alveoli<\/span> or at the air-epithelium interface, the once stable suspensions of the respective nanoparticles (SiO<sub>2<\/sub> FITC, adsorptively labelled ZrO<sub>2<\/sub>) agglomerated over the entire observation period (30 &#x2013; 180 min) resulting from the interaction with the proteins of the lung alveoli.<\/p>\n<p>Within the topic<strong> &#x201C;<span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_29fd131a0d512eb1f0aa4ee91141bd26\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">nanoparticle<\/span> toxicology: material properties and effects&#x201D;<\/strong>, <em><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_fdb8b55a8eca6aa21c3383e316dcdca4\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">in vitro<\/span><\/em> and <em><span class=\"glossaryLink\"  aria-describedby=\"tt\"  data-cmtooltip=\"cmtt_2cb317d76819b4b18aa07955f03a8942\"  data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex='0' role='link'>in vivo<\/span><\/em> analyses were carried out on sensitised mice, among others. Whereas, in both scenarios, the unmodified silicon dioxide nanomaterials were found to cause the strongest effects, no significant reactions were observed in the amino- and phosphate-functionalised SiO<sub>2<\/sub> materials. The risk-related studies revealed that the risk potential of a substance can be changed through <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_439563b6b04a646cc54082ee567f43a1\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">surface modification<\/span> and that this may lead to a better matrix integration.<\/p>\n<p>For <strong>risk assessment<\/strong>, various data on chemical safety, occupational health and safety, and consumer protection were compiled and evaluated. For the derivation of the risk assessment of nanomaterials within the context of chemical safety legislation specific data on the endpoints related to the three selected <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"cmtt_3ddd56a982b62f20c8279dbc63e14262\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">nanoscale<\/span> materials silicon dioxide, silver, and zirconium dioxide were collected and analysed. The evaluation revealed that, in view of the fact that no solely nano-specific modes of action have been identified so far and that conventional risk assessment principles can also be applied to nanomaterials.<\/p>\n<p><img decoding=\"async\" class=\"alignleft wp-image-9366\" title=\"Wohlleben W., Kuhlbusch T.A.J., Schnekenburger J., Lehr C.M. (2015). Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards. Taylor &amp; Francis Inc, CRC Press, pp. 472. ISBN: 9781466567863.\" src=\"https:\/\/nanopartikel.info\/wp-content\/uploads\/2020\/11\/2015-02-09-safety-of-nanomaterials-book.jpg\" alt=\"Wohlleben W., Kuhlbusch T.A.J., Schnekenburger J., Lehr C.M. (2015). Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards. Taylor &amp; Francis Inc, CRC Press, pp. 472. ISBN: 9781466567863.\" width=\"100\" height=\"160\" srcset=\"https:\/\/materialneutral.info\/wp-content\/uploads\/2020\/11\/2015-02-09-safety-of-nanomaterials-book.jpg 406w, https:\/\/materialneutral.info\/wp-content\/uploads\/2020\/11\/2015-02-09-safety-of-nanomaterials-book-188x300.jpg 188w\" sizes=\"(max-width: 100px) 100vw, 100px\"\/><\/p>\n<p>&#xA0;<\/p>\n<p>&#xA0;<\/p>\n<p>Wohlleben W., Kuhlbusch T.A.J., Schnekenburger J., Lehr C.M. (2015). S<em>afety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards<\/em>. Taylor &amp; Francis Inc, CRC Press, pp. 472. <a title=\"Wohlleben W., Kuhlbusch T.A.J., Schnekenburger J., Lehr C.M. (2015). Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards. Taylor &amp; Francis Inc, CRC Press, pp. 472. ISBN: 9781466567863.\" href=\"https:\/\/www.routledge.com\/Safety-of-Nanomaterials-along-Their-Lifecycle-Release-Exposure-and-Human\/Wohlleben-Kuhlbusch-Schnekenburger-Lehr\/p\/book\/9781466567863\" target=\"_blank\" rel=\"noopener noreferrer\">ISBN: 9781466567863<\/a>.<\/p>\n<p>&#xA0;<\/p>\n","protected":false},"template":"","cluster":[523],"modul":[],"class_list":["post-9519","project","type-project","status-publish","hentry","cluster-2009-2014-nanocare-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>nanoGEM - MANTRA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/materialneutral.info\/en\/project\/nanogem\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"nanoGEM - MANTRA\" \/>\n<meta property=\"og:description\" content=\"nanoGEM &#8211; 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